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Circe effect : ウィキペディア英語版 | Circe effect The Circe Effect is a phenomenon proposed by William Jencks seen in chemistry and biochemistry where in order to speed up a reaction, the ground state of the substrate is destabilized by an enzyme. ==Mechanism== Highly favourable binding of a substrate at a non-reactive site will force the reactive site of the substrate to be more reactive by putting it in a very unfavourable position. This effect was observed in Orotidine 5'-phosphate decarboxylase This can occur by proving a charged amino acid group next to the charged substrate thus destabilizing it, thus making the reaction occur faster. Furthermore, the substrate is put into a very optimal position by the enzyme for the reaction to occur, thus decreasing the entropy greatly.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Circe effect」の詳細全文を読む
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